BDBM699261 2'-chloro-N-{5- [difluoro(methylcarbamoyl) Methoxy]-1,3-benzothiazol-2-yl}-5'- methoxy-6-methyl- [4,4'-bipyridine]-3-carboxamide::US20240327430, Example 102

SMILES CNC(=O)C(F)(F)Oc1ccc2sc(NC(=O)c3cnc(C)cc3-c3cc(Cl)ncc3OC)nc2c1

InChI Key InChIKey=DNJGXHMVILQWRL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699261   

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699261(2'-chloro-N-{5- [difluoro(methylcarbamoyl) Methoxy...)
Affinity DataIC50: 100nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Polθ protein (P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2025
Entry Details
US Patent

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699261(2'-chloro-N-{5- [difluoro(methylcarbamoyl) Methoxy...)
Affinity DataIC50: 1.00E+3nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Pol&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
US Patent