BDBM699276 N-[5-(4-hydroxypiperidin-1-yl)- [1,3]thiazolo[5,4-d]pyrimidin-2-yl]-5'- methoxy-2',6-dimethyl-[4,4'- bipyridine]-3-carboxamide::US20240327430, Example 117

SMILES COc1cnc(C)cc1-c1cc(C)ncc1C(=O)Nc1nc2cnc(nc2s1)N1CCC(O)CC1

InChI Key InChIKey=WWBGJSGLHNAFRJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 699276   

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699276(N-[5-(4-hydroxypiperidin-1-yl)- [1,3]thiazolo[5,4-...)
Affinity DataIC50: 100nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Polθ protein (P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2025
Entry Details
US Patent

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM699276(N-[5-(4-hydroxypiperidin-1-yl)- [1,3]thiazolo[5,4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Pol&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2025
Entry Details
US Patent