BDBM699346 (E)-1-[3-[4-(hydroxymethyl)-1-[4- (trifluoromethoxy)phenyl]pyrazolo[3,4- b]pyridin-3-yl]azetidin-1-yl]-4- methoxy-but-2-en-1-one::US12110276, Compound 40

SMILES COC\C=C\C(=O)N1CC(C1)c1nn(-c2ccc(OC(F)(F)F)cc2)c2nccc(CO)c12

InChI Key InChIKey=VHNVPSRUKRQDKQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699346   

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699346((E)-1-[3-[4-(hydroxymethyl)-1-[4- (trifluoromethox...)
Affinity DataIC50: 13nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699346((E)-1-[3-[4-(hydroxymethyl)-1-[4- (trifluoromethox...)
Affinity DataIC50: 16nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699346((E)-1-[3-[4-(hydroxymethyl)-1-[4- (trifluoromethox...)
Affinity DataIC50: 48nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699346((E)-1-[3-[4-(hydroxymethyl)-1-[4- (trifluoromethox...)
Affinity DataIC50: 66nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent