BDBM699385 3-[1-[(E)-4-hydroxybut-2- enoyl]azetidin-3-yl]-1-[4- (trifluoromethoxy)phenyl]pyrazolo[3,4- b]pyridine-4-carbonitrile::US12110276, Compound 79

SMILES OC\C=C\C(=O)N1CC(C1)c1nn(-c2ccc(OC(F)(F)F)cc2)c2nccc(C#N)c12

InChI Key InChIKey=IEDCMMDQOKHGLE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699385   

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699385(3-[1-[(E)-4-hydroxybut-2- enoyl]azetidin-3-yl]-1-[...)
Affinity DataIC50: 6.80nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699385(3-[1-[(E)-4-hydroxybut-2- enoyl]azetidin-3-yl]-1-[...)
Affinity DataIC50: 19nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699385(3-[1-[(E)-4-hydroxybut-2- enoyl]azetidin-3-yl]-1-[...)
Affinity DataIC50: 20nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699385(3-[1-[(E)-4-hydroxybut-2- enoyl]azetidin-3-yl]-1-[...)
Affinity DataIC50: 60nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent