BDBM700952 N-(5-amino-2-((2-(azetidin-1- yl)ethyl)(methyl)amino)-4- methoxyphenyl)acrylamide trifluoroacetic acid salt::US20240343694, Example 82

SMILES C=CC(=O)Nc1cc(N)c(OC)cc1N(C)CCN1CCC1

InChI Key InChIKey=GMOJWMXXMHKPNP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 700952   

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700952(N-(5-amino-2-((2-(azetidin-1- yl)ethyl)(methyl)ami...)
Affinity DataIC50: 1nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-763,'FHEA',764-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700952(N-(5-amino-2-((2-(azetidin-1- yl)ethyl)(methyl)ami...)
Affinity DataIC50: 1nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700952(N-(5-amino-2-((2-(azetidin-1- yl)ethyl)(methyl)ami...)
Affinity DataIC50: 2nMAssay Description:The activity of the compounds of the present invention against HER mutant enzymes was measured using the HTRF system purchased by Cisbio as follows. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent