BDBM700973 US20240343694, Example 62::isopropyl 2-chloro-4-((1- (methylsulfonyl)-1,2,3,4- tetrahydroquinolin-8- yl)amino)pyrimidin-5-carboxylate

SMILES CC(C)OC(=O)c1cnc(Cl)nc1Nc1cccc2c1N(S(C)(=O)=O)CCC2

InChI Key InChIKey=DFGJTNCAEIONPM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 700973   

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700973(isopropyl 2-chloro-4-((1- (methylsulfonyl)-1,2,3,4...)
Affinity DataIC50: 3nMAssay Description:The activity of the compounds of the present invention against HER mutant enzymes was measured using the HTRF system purchased by Cisbio as follows. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent