BDBM701995 4-(6-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(1-(methyl-d3)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile::US12129266, Example 5

SMILES [2H]C([2H])([2H])n7ccc(c6cc(c4ccc(N1CC2CC(C1)N2C([2H])([2H])c3ccc(OC)nc3)nc4)c5c(C#N)cnn5c6)c7

InChI Key InChIKey=NUMKPIDNZASUGC-GJZIZAJSSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 701995   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701995(4-(6-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 0.110nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM701995(4-(6-(6-((6-methoxypyridin-3-yl)methyl-d2)-3,6-dia...)
Affinity DataIC50: 0.230nMAssay Description:In 5x kinase buffer solution A, Ret wt or RET V804M kinase was mixed with pre-formulated and diluted compounds of different concentrations for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
US Patent