BDBM703885 4-methyl-7-(pyridin-3-yl)-1,5-paphthyridin-2- amine LCMS [M + 1]: 237.2. 1H NMR (400 MHz, MeOD) $#948; = 8.94 (dd, J = 0.8, 2.4 Hz, 1H), 8.81 (d, J = 2.0 Hz, 1H), 8.62 (dd, J = 1.6, 4.8 Hz, 1H), 8.26-8.17 (m, 1H), 8.07 (d, J = 2.0 Hz, 1H), 7.60 (ddd, J = 0.8, 4.8, 8.0 Hz, 1H), 6.95 (d, J = 0.8 Hz, 1H), 2.66 (d, J = 0.8 Hz, 3H)::US20240368153, Example 1-3

SMILES Cc1cc(N)nc2cc(-c3cccnc3)cnc12

InChI Key InChIKey=PJNYMJYHWXXOBJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 703885   

LigandChemical structure of BindingDB Monomer ID 703885BDBM703885(4-methyl-7-(pyridin-3-yl)-1,5-paphthyridin-2- amin...)
Affinity DataIC50: 2.09E+3nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent