BDBM703897 4-methyl-7-(2-pyridylmethyl)-1,5-naphthyridin-2- amine. LCMS [M + 1]: 251.2. 1H NMR (400 MHz, MeOD-d4) $#948; = 8.51 (dd, J = 0.8, 5.2 Hz, 1H), 8.50 (d, J = 2.0 Hz, 1H), 7.82 (dt, J = 2.0, 7.6 Hz, 1H), 7.72-7.68 (m, 1H), 7.42 (d, J = 7.6 Hz, 1H), 7.32 (ddd, J = 0.8, 5.6, 6.8 Hz, 1H), 6.89 (d, J = 1.2 Hz, 1H), 4.33 (s, 2H), 2.62 (d, J = 1.2 Hz, 3H).::US20240368153, Example 2-6

SMILES Cc1cc(N)nc2cc(Cc3ccccn3)cnc12

InChI Key InChIKey=MPWNZOJWCJGJAN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 703897   

LigandChemical structure of BindingDB Monomer ID 703897BDBM703897(4-methyl-7-(2-pyridylmethyl)-1,5-naphthyridin-2- a...)
Affinity DataIC50: 2.85E+3nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
3/14/2025
Entry Details
US Patent