BDBM703914 6-isothiazol-4-yl-4-methyl-1,5-naphthyridin-2- amine. LCMS [M + 1] = 243.2. 1H NMR (400 MHz, MeOD-d4) $#948; = 9.43 (s, 1H), 9.23 (s, 1H), 7.99 (d, J = 8.6 Hz, 1H), 7.88 (d, J = 8.6 Hz, 1H), 6.94 (d, J = 0.8 Hz, 1H), 2.71 (s, 3H).::US20240368153, Example 4-6

SMILES Cc1cc(N)nc2ccc(-c3cnsc3)nc12

InChI Key InChIKey=PGPUVCKLYDWKLT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 703914   

LigandChemical structure of BindingDB Monomer ID 703914BDBM703914(6-isothiazol-4-yl-4-methyl-1,5-naphthyridin-2- ami...)
Affinity DataIC50: 2.18E+4nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
3/14/2025
Entry Details
US Patent