BDBM703918 N6-cyclobutyl-4-methyl-1,5-naphthyridine-2,6- diamine. LCMS [M + 1] = 229.0. 1H NMR (400 MHz, CDCl3) $#948; = 7.69 (d, J = 8.8 Hz, 1 H), 6.70 (s, 1 H), 6.68 (s, 1 H), 4.74 (br d, J = 4.4 Hz, 1 H), 4.46-4.34 (m, 3 H), 2.57 (d, J = 0.8 Hz, 3 H), 2.53-2.45 (m, 2 H), 1.96-1.88 (m, 2 H), 1.85- 1.77 (m, 2 H).::US20240368153, Example 5-3

SMILES Cc1cc(N)nc2ccc(NC3CCC3)nc12

InChI Key InChIKey=MEJQMLQMZHMAFM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 703918   

LigandChemical structure of BindingDB Monomer ID 703918BDBM703918(N6-cyclobutyl-4-methyl-1,5-naphthyridine-2,6- diam...)
Affinity DataIC50: 8.79E+4nMAssay Description:Table A1: A recombinant human dual expressed Avi PRMT5/His-MEP50) protein (corresponding to amino acids for PRMT5 2-637, and 2-342 for MEP50 expresse...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
US Patent