BDBM703970 (S)-6-amino-N-((5-bromopyridin- 2-yl)methyl)-7-methyl-N-(1- (pyrimidin-2-yl)ethyl)-1,5- naphthyridine-3-carboxamide LCMS [M + 1]+ = 480.0. 1H NMR (400 MHz, MeOD-d4) $#948; = 8.82- 8.43 (m, 4H), 8.20-7.98 (m, 1H), 7.95-7.75 (m, 2H), 7.45-7.16 (m, 2H), 5.92-5.25 (m, 1H), 4.96 (br d, J = 16.4 Hz, 1H), 4.61 (br d, J = 16.4 Hz, 1H), 2.42-2.27 (m, 3H), 1.68 (br d, J = 7.2 Hz, 3H)::US20240368153, Example 10-7

SMILES Cc1cc2ncc(C(=O)N(Cc3ccc(Br)cn3)[C@@H](C)c3ncccn3)cc2nc1N

InChI Key InChIKey=DPKMKUVJFYPCMO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 703970   

LigandChemical structure of BindingDB Monomer ID 703970BDBM703970((S)-6-amino-N-((5-bromopyridin- 2-yl)methyl)-7-met...)
Affinity DataIC50: 1.62E+4nMAssay Description:Table B2: The assay uses recombinant full-length histone H2A as the PRMT5 substrate. Enzymatic transfer of the tritiated methyl group from S-adenosyl...More data for this Ligand-Target Pair
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Date in BDB:
3/14/2025
Entry Details
US Patent