BDBM704438 5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpholinoanilino)pyrazine-2-carboxamide::US20240374606, Example 2

SMILES Cc1nc(Nc2ccc(N3CCOCC3)cc2)c(C(N)=O)nc1-c1cccc2c1ncn2C

InChI Key InChIKey=BNESJBZBRJSCLR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 704438   

LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 5nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 5.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 158nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 158nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetLymphocyte cytosolic protein 2(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 1.20E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataEC50:  2.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTyrosine-protein kinase Lck(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 1.98E+4nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Lck(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 704438BDBM704438(5-Methyl-6-(1-methylbenzimidazol-4-yl)-3-(4-morpho...)
Affinity DataIC50: 1.98E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed