BDBM704615 3-[3,5-Difluoro-4-[(1-methyl-4-piperidyl)oxy]anilino]-5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide::US20240374606, Example 168

SMILES CNc1nc(Nc2cc(F)c(OC3CCN(C)CC3)c(F)c2)c(C(N)=O)nc1-c1cncc2c1ncn2C

InChI Key InChIKey=REAMBIDJUBDLKK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 704615   

LigandPNGBDBM704615(3-[3,5-Difluoro-4-[(1-methyl-4-piperidyl)oxy]anili...)
Affinity DataIC50: 3nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandPNGBDBM704615(3-[3,5-Difluoro-4-[(1-methyl-4-piperidyl)oxy]anili...)
Affinity DataIC50: 4nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Lck(Human)
Astrazeneca

US Patent
LigandPNGBDBM704615(3-[3,5-Difluoro-4-[(1-methyl-4-piperidyl)oxy]anili...)
Affinity DataIC50: 244nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent