BDBM704659 5-Cyclopropyl-3-[(1,3-dimethylpyrazol-4-yl)amino]-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide::US20240374606, Example 212

SMILES Cc1nn(C)cc1Nc1nc(C2CC2)c(-c2cncc3c2ncn3C)nc1C(N)=O

InChI Key InChIKey=DVTSMPKZIZMYQF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 704659   

LigandChemical structure of BindingDB Monomer ID 704659BDBM704659(5-Cyclopropyl-3-[(1,3-dimethylpyrazol-4-yl)amino]-...)
Affinity DataIC50: 3nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704659BDBM704659(5-Cyclopropyl-3-[(1,3-dimethylpyrazol-4-yl)amino]-...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetLymphocyte cytosolic protein 2(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704659BDBM704659(5-Cyclopropyl-3-[(1,3-dimethylpyrazol-4-yl)amino]-...)
Affinity DataIC50: 48nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 704659BDBM704659(5-Cyclopropyl-3-[(1,3-dimethylpyrazol-4-yl)amino]-...)
Affinity DataEC50:  66nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 704659BDBM704659(5-Cyclopropyl-3-[(1,3-dimethylpyrazol-4-yl)amino]-...)
Affinity DataIC50: 91nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 704659BDBM704659(5-Cyclopropyl-3-[(1,3-dimethylpyrazol-4-yl)amino]-...)
Affinity DataIC50: 91nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTyrosine-protein kinase Lck(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704659BDBM704659(5-Cyclopropyl-3-[(1,3-dimethylpyrazol-4-yl)amino]-...)
Affinity DataIC50: 5.10E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTyrosine-protein kinase Lck(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704659BDBM704659(5-Cyclopropyl-3-[(1,3-dimethylpyrazol-4-yl)amino]-...)
Affinity DataIC50: 5.13E+3nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent