BDBM704664 3-[[1-(1-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]amino]-5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxamide::US20240374606, Example 217

SMILES Cc1nn(C2(C#N)CC2)cc1Nc1nc(C2CC2)c(-c2cncc3c2ncn3C)nc1C(N)=O

InChI Key InChIKey=TUDWPNWFIZWQOZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 704664   

LigandChemical structure of BindingDB Monomer ID 704664BDBM704664(3-[[1-(1-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]a...)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 704664BDBM704664(3-[[1-(1-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]a...)
Affinity DataIC50: 5nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetLymphocyte cytosolic protein 2(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704664BDBM704664(3-[[1-(1-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]a...)
Affinity DataIC50: 198nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 704664BDBM704664(3-[[1-(1-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]a...)
Affinity DataEC50:  250nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 704664BDBM704664(3-[[1-(1-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]a...)
Affinity DataIC50: 260nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 704664BDBM704664(3-[[1-(1-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]a...)
Affinity DataIC50: 490nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Lck(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704664BDBM704664(3-[[1-(1-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]a...)
Affinity DataIC50: 1.80E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetTyrosine-protein kinase Lck(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 704664BDBM704664(3-[[1-(1-Cyanocyclopropyl)-3-methyl-pyrazol-4-yl]a...)
Affinity DataIC50: 3.19E+4nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced in a kinase assay in the presence and absence of the compound(s) a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent