BDBM705199 N-((4-((((S)-1,4-dioxan-2-yl)methyl)amino)-3-nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(2-((R or S)-2-(2-isopropylphenyl)-4-(4-methoxybenzyl)piperazin-1-yl)-7-azaspiro[3.5]nonan-7-yl)benzamide::US20240376097, Example 33

SMILES COc%10ccc(CN9CCN(C7CC6(CCN(c5ccc(C(=O)NS(=O)(=O)c2ccc(NC[C@H]1COCCO1)c([N+](=O)[O-])c2)c(Oc4cnc3[nH]ccc3c4)c5)CC6)C7)[C@H](c8ccccc8C(C)C)C9)cc%10

InChI Key InChIKey=OETCJAKDQAWUER-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 705199   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705199BDBM705199(N-((4-((((S)-1,4-dioxan-2-yl)methyl)amino)-3-nitro...)
Affinity DataIC50: 0.0380nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [D103Y](Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705199BDBM705199(N-((4-((((S)-1,4-dioxan-2-yl)methyl)amino)-3-nitro...)
Affinity DataIC50: 0.0940nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2D 103Y protein with its ligand in an assay based on time-resolved fluorescence r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent