BDBM705203 2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-(((5-(hydroxymethyl) tetrahydrofuran-2-yl)methyl) amino)-3-nitrophenyl)sulfonyl)-4- (2-((R)-2-(2-isopropylphenyl)-4-(4- methoxybenzyl)piperazin-1-yl)-7- azaspiro[3.5]nonan-7-yl) benzamide::US20240376097, Example 220

SMILES COc1ccc(CN2CCN(C3CC4(CCN(c5ccc(C(=O)NS(=O)(=O)c6ccc(NCC7CCC(CO)O7)c([N+](=O)[O-])c6)c(Oc6cnc7[nH]ccc7c6)c5)CC4)C3)[C@H](c3ccccc3C(C)C)C2)cc1

InChI Key InChIKey=VAZPDXWYSBYSIN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 705203   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705203BDBM705203(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-(((5...)
Affinity DataIC50: 0.0440nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2 [D103Y](Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705203BDBM705203(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-(((5...)
Affinity DataIC50: 0.0770nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2D 103Y protein with its ligand in an assay based on time-resolved fluorescence r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent