BDBM705458 2''-chloro-N-(5-{[(2S)-2- hydroxypropyl]amino}- [1,3]thiazolo[5,4-d]pyrimidin-2-yl)-5''- methoxy-6-methyl-[4,4''-bipyridine]-3- carboxamide::US12145945, Example 96

SMILES COc1cnc(Cl)cc1c2cc(C)ncc2C(=O)Nc4nc3cnc(CC[C@H](C)O)nc3s4

InChI Key InChIKey=JVJJOVHPEXWHLC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 705458   

TargetDNA polymerase theta(Human)
Breakpoint Therapeutics

US Patent
LigandPNGBDBM705458(2'-chloro-N-(5-{[(2S)-2- hydroxypropyl]amino}- [1,...)
Affinity DataIC50: 100nMAssay Description:The Polθ ATPase assay was used to evaluate inhibitors of Polθ ATPase activity, in vitro. Experiments were performed using a truncated Polθ protein (P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
4/8/2025
Entry Details
US Patent