BDBM705478 N-(5-((1S,5S,6S)-3-amino-1-(fluoromethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-6-fluoropyridin-3-yl)-5-(prop-2-yn-1-yloxy)pyrazine-2-carboxamide::US20160046618, Example 606

SMILES C#CCOc1cnc(C(=O)Nc2cnc(F)c([C@@]3(C)N=C(N)S[C@@]4(CF)C[C@H]43)c2)cn1

InChI Key InChIKey=MPLHANQZLPTTKT-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 705478   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM705478(N-(5-((1S,5S,6S)-3-amino-1-(fluoromethyl)-5-methyl...)
Affinity DataIC50: 0.320nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM705478(N-(5-((1S,5S,6S)-3-amino-1-(fluoromethyl)-5-methyl...)
Affinity DataIC50: 9.31nMAssay Description:The cDNAs for both human recombinant BACE1 and BACE2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM705478(N-(5-((1S,5S,6S)-3-amino-1-(fluoromethyl)-5-methyl...)
Affinity DataIC50: 2.78E+5nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/9/2025
Entry Details
US Patent