BDBM706664 US20240383922, Example 6-17

SMILES C#Cc1c(F)ccc2cc(O)cc(-c3nc4c5c(nc(OC[C@@]67CCCN6C[C@H](F)C7)nc5c3F)N3CC(F)(F)COCC3CC4)c12

InChI Key InChIKey=JXPDRIYJJRUYLN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 706664   

TargetGTPase KRas [G12C](Human)
Gilead Sciences

US Patent
LigandPNGBDBM706664(US20240383922, Example 6-17)
Affinity DataIC50: 0.370nMAssay Description:Compounds were tested for binding to GDP-loaded wild-type KRAS (WT), KRAS-G12C, KRAS-G12D, and KRAS-G12V in a 384-well assay format using a TR-FRET p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Gilead Sciences

US Patent
LigandPNGBDBM706664(US20240383922, Example 6-17)
Affinity DataIC50: 1.21nMAssay Description:Compounds were tested for binding to GDP-loaded wild-type KRAS (WT), KRAS-G12C, KRAS-G12D, and KRAS-G12V in a 384-well assay format using a TR-FRET p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
US Patent

TargetGTPase KRas [G12V](Human)
Gilead Sciences

US Patent
LigandPNGBDBM706664(US20240383922, Example 6-17)
Affinity DataIC50: 1.25nMAssay Description:Compounds were tested for binding to GDP-loaded wild-type KRAS (WT), KRAS-G12C, KRAS-G12D, and KRAS-G12V in a 384-well assay format using a TR-FRET p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Gilead Sciences

US Patent
LigandPNGBDBM706664(US20240383922, Example 6-17)
Affinity DataIC50: 1.31nMAssay Description:Compounds were tested for binding to GDP-loaded wild-type KRAS (WT), KRAS-G12C, KRAS-G12D, and KRAS-G12V in a 384-well assay format using a TR-FRET p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/12/2025
Entry Details
US Patent