BDBM707374 (2S,3R)-1-{5-methoxy-4-[1-(1- methyl-3-azetidinyl)-4-pyrazolyl]- 6-(trifluoromethyl)-2- pyrimidinyl}-2-methyl-3- azetidinol::US20240409530, Compound A8

SMILES COc1c(-c2cnn(C3CN(C)C3)c2)nc(N2C[C@@H](O)[C@@H]2C)nc1C(F)(F)F

InChI Key InChIKey=PFYPSKZHMABEIF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 707374   

TargetIsoform A of Ketohexokinase (Peripheral)(Rattus norvegicus (Rat))
Centennial Therapeutics

US Patent
LigandPNGBDBM707374((2S,3R)-1-{5-methoxy-4-[1-(1- methyl-3-azetidinyl)...)
Affinity DataIC50: 5.5nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetKetohexokinase(Human)
Centennial Therapeutics

US Patent
LigandPNGBDBM707374((2S,3R)-1-{5-methoxy-4-[1-(1- methyl-3-azetidinyl)...)
Affinity DataIC50: 6.46nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Centennial Therapeutics

US Patent
LigandPNGBDBM707374((2S,3R)-1-{5-methoxy-4-[1-(1- methyl-3-azetidinyl)...)
Affinity DataIC50: 7.80nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetKetohexokinase(Rat)
Centennial Therapeutics

US Patent
LigandPNGBDBM707374((2S,3R)-1-{5-methoxy-4-[1-(1- methyl-3-azetidinyl)...)
Affinity DataIC50: 16nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent