BDBM707577 US20240409609, Compound 107

SMILES CN1CCN(Cc2ccc3[nH]/c(=NC(=O)c4cc(Oc5cccc(O)c5C=O)c5sccc5c4)n(CC(C)(C)O)c3c2)CC1

InChI Key InChIKey=XOVSDWSJRWXBPP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 707577   

TargetEpidermal growth factor receptor [T790M,C797S,L858R](Homo sapiens (Human))
Terremoto Biosciences

US Patent
LigandPNGBDBM707577(US20240409609, Compound 107)
Affinity DataIC50: 0.904nMAssay Description:Biochemical activity was determined using a chelation-enhanced fluorescence assay. EGFR enzyme was incubated with DMSO-dissolved inhibitors in reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707577(US20240409609, Compound 107)
Affinity DataIC50: 1.80nMAssay Description:Biochemical activity was determined using a chelation-enhanced fluorescence assay. EGFR enzyme was incubated with DMSO-dissolved inhibitors in reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Terremoto Biosciences

US Patent
LigandPNGBDBM707577(US20240409609, Compound 107)
Affinity DataIC50: 8.71nMAssay Description:Biochemical activity was determined using a chelation-enhanced fluorescence assay. EGFR enzyme was incubated with DMSO-dissolved inhibitors in reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
US Patent