BDBM708080 (S)-2-(2-(2-chlorophenyl)-4- (pyridin-2-yl)piperazin-1- yl)-5-hydroxy-N-(isoxazol- 4-yl)-1-methyl-6-oxo-1,6- dihydropyrimidine-4- carboxamide::US12172990, Example 125

SMILES Cn1c(N2CCN(c3ccccn3)C[C@@H]2c2ccccc2Cl)nc(C(=O)Nc2cnoc2)c(O)c1=O

InChI Key InChIKey=KRQZXKCQZQRYFY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 708080   

TargetThree-prime repair exonuclease 1(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708080((S)-2-(2-(2-chlorophenyl)-4- (pyridin-2-yl)piperaz...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetThree prime repair exonuclease 2(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM708080((S)-2-(2-(2-chlorophenyl)-4- (pyridin-2-yl)piperaz...)
Affinity DataIC50: 10nMAssay Description:Compound potency was assessed through a fluorescence assay measuring degradation of a custom dsDNA substrate possessing a fluorophore-quencher pair o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent