BDBM708089 US12172992, Example 5

SMILES Cc6cc(c5cc(Nc4ccc(N3CCN(CCc2ccc(N1CCC(=O)NC1=O)c(F)c2)C[C@H]3C)cn4)ncn5)ccc6[C@@H](C)NC(=O)c7nc(C(C)(C)C)no7

InChI Key InChIKey=XZWLTIJDAOOAOZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 708089   

TargetTyrosine-protein kinase BTK(Human)
Abbvie

US Patent
LigandPNGBDBM708089(US12172992, Example 5)
Affinity DataIC50: 0.113nMAssay Description:Btk kinase activity was measured in vitro using an electrophoretic mobility shift assay (MSA). The ability of Btk to phosphorylate a fluorescent pept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent

TargetProtein cereblon(Human)
Abbvie

US Patent
LigandPNGBDBM708089(US12172992, Example 5)
Affinity DataIC50: 648nMAssay Description:Competition Assay: Test compounds in 100% dimethyl sulfoxide were plated onto white, low volume 384 well plates (PerkinElmer Proxiplate 384 plus #600...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/5/2025
Entry Details
US Patent