BDBM708315 US20240423977, Example I-2

SMILES COc8cc7nn(C6CC5(CCN(CC(=O)N4CCN(c3ccc2c(=O)n(C1CCC(=O)NC1=O)c(=O)c2c3)CC4)CC5)C6)cc7cc8NC(=O)c9cccc(C(F)(F)F)n9

InChI Key InChIKey=NRBAYLUOFQZGKZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 708315   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Hangzhou Polymed Biopharmaceuticals

US Patent
LigandPNGBDBM708315(US20240423977, Example I-2)
Affinity DataIC50: 11nMAssay Description:1) IRAK4 kinase was dissolved in kinase buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, 2 mM DTT and 0.01% Brij-35) to a final concentration of 6 nM.[0542]2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Hangzhou Polymed Biopharmaceuticals

US Patent
LigandPNGBDBM708315(US20240423977, Example I-2)
Affinity DataIC50: 100nMAssay Description:1) IRAK4 kinase was dissolved in kinase buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, 2 mM DTT and 0.01% Brij-35) to a final concentration of 6 nM.[0542]2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent