BDBM708335 US20240423977, Example I-10

SMILES O=C1CCC(N2C(=O)c3ccc(N4CCC(C(=O)N5CCC6(CC5)CC(n5cc7cc(NC(=O)c8cccc(C(F)(F)F)n8)c(N8CC[C@@H](O)C8)cc7n5)C6)CC4)cc3C2=O)C(=O)N1

InChI Key InChIKey=USJWSBGZBBIHHZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 708335   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Hangzhou Polymed Biopharmaceuticals

US Patent
LigandPNGBDBM708335(US20240423977, Example I-10)
Affinity DataIC50: 24nMAssay Description:1) IRAK4 kinase was dissolved in kinase buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, 2 mM DTT and 0.01% Brij-35) to a final concentration of 6 nM.[0542]2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/7/2025
Entry Details
US Patent