BDBM709617 (E)-6-(1-(1-((1-(4- (dimethylamino)but-2- enoyl)azetidin-3- yl)methyl)azetidin- 3-yl)-1H-pyrazol-4- methoxypyrazolo [1,5-a]pyridine-3-carbonitrile::US12180207, Example 148

SMILES COc1cc(-c2cnn(C3CN(CC4CN(C(=O)/C=C/CN(C)C)C4)C3)c2)cn2ncc(C#N)c12

InChI Key InChIKey=VEXULJTWOHELIA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 709617   

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 709617BDBM709617((E)-6-(1-(1-((1-(4- (dimethylamino)but-2- enoyl)az...)
Affinity DataIC50: 4nMAssay Description:FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 709617BDBM709617((E)-6-(1-(1-((1-(4- (dimethylamino)but-2- enoyl)az...)
Affinity DataIC50: 6nMAssay Description:FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 709617BDBM709617((E)-6-(1-(1-((1-(4- (dimethylamino)but-2- enoyl)az...)
Affinity DataIC50: 14nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 709617BDBM709617((E)-6-(1-(1-((1-(4- (dimethylamino)but-2- enoyl)az...)
Affinity DataIC50: 47nMAssay Description:FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 709617BDBM709617((E)-6-(1-(1-((1-(4- (dimethylamino)but-2- enoyl)az...)
Affinity DataIC50: 217nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent