BDBM709644 (E)-4-methoxy-6- (1-(1-((1-(4- (piperidin-1-yl)but- 2-enoyl)azetidin-3- yl)methyl)piperidin- 4-yl)-1H-pyrazol- 4-yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US12180207, Example 175

SMILES COc1cc(-c2cnn(C3CCN(CC4CN(C(=O)/C=C/CN5CCCCC5)C4)CC3)c2)cn2ncc(C#N)c12

InChI Key InChIKey=AMBHRMBNIWIRML-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 709644   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709644((E)-4-methoxy-6- (1-(1-((1-(4- (piperidin-1-yl)but...)
Affinity DataIC50: 4nMAssay Description:FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709644((E)-4-methoxy-6- (1-(1-((1-(4- (piperidin-1-yl)but...)
Affinity DataIC50: 5nMAssay Description:FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM709644((E)-4-methoxy-6- (1-(1-((1-(4- (piperidin-1-yl)but...)
Affinity DataIC50: 8nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM709644((E)-4-methoxy-6- (1-(1-((1-(4- (piperidin-1-yl)but...)
Affinity DataIC50: 10nMAssay Description:FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphorylation b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM709644((E)-4-methoxy-6- (1-(1-((1-(4- (piperidin-1-yl)but...)
Affinity DataIC50: 90nMAssay Description:he potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Fluorescence (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/12/2025
Entry Details
US Patent