BDBM709748 2-[(5''S,7a''R)-5''-(3,5- difluorophenyl)-3''- oxotetrahydro-1H,3''H- spiro[piperidine-4,2''- pyrrolo[2,1-b] [1,3]oxazol]-1-yl]-4- methoxypyrimidine-5- carbonitrile::US12180226, Example 4.38

SMILES COc1nc(N2CCC3(CC2)O[C@@H]2CC[C@@H](c4cc(F)cc(F)c4)N2C3=O)ncc1C#N

InChI Key InChIKey=UWMIYVJNLVFJIX-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 709748   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM709748(2-[(5'S,7a'R)-5'-(3,5- difluorophenyl)-3'- oxotetr...)
Affinity DataEC50:  1.20E+4nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
5/12/2025
Entry Details
US Patent