BDBM710725 2-(6-(cyclopentylamino)-4-((1R,3S)-3- methyl-1-(4-methyl-4H-1,2,4-triazol-3- yl)cyclobutyl)pyridin-2-yl)-6-(((S)-2- isopropyl-4-methylpiperazin-1-yl)methyl)- 4-(trifluoromethyl)isoindolin-1-one::US12187709, Compound 75

SMILES CC(C)[C@H]1CN(C)CCN1Cc1cc2c(c(C(F)(F)F)c1)CN(c1cc([C@]3(c4nncn4C)C[C@H](C)C3)cc(NC3CCCC3)n1)C2=O

InChI Key InChIKey=PJLNANCIFHCOOI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710725   

LigandChemical structure of BindingDB Monomer ID 710725BDBM710725(2-(6-(cyclopentylamino)-4-((1R,3S)-3- methyl-1-(4-...)
Affinity DataIC50: 17nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710725BDBM710725(2-(6-(cyclopentylamino)-4-((1R,3S)-3- methyl-1-(4-...)
Affinity DataIC50: 22nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710725BDBM710725(2-(6-(cyclopentylamino)-4-((1R,3S)-3- methyl-1-(4-...)
Affinity DataKd:  31nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710725BDBM710725(2-(6-(cyclopentylamino)-4-((1R,3S)-3- methyl-1-(4-...)
Affinity DataKd:  230nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent