BDBM710791 (S)-6-(2-hydroxy-1-((1- methylcyclobutyl)amino)ethyl)-2-(3-(1-(4- methyl-4H-1,2,4-triazol-3- yl)cyclobutyl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US12187709, Compound 149

SMILES Cn1cnnc1C1(c2cccc(N3Cc4c(cc([C@@H](CO)NC5(C)CCC5)cc4C(F)(F)F)C3=O)c2)CCC1

InChI Key InChIKey=ZDPCJOGRIURSJF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710791   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM710791((S)-6-(2-hydroxy-1-((1- methylcyclobutyl)amino)eth...)
Affinity DataKd:  0.300nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM710791((S)-6-(2-hydroxy-1-((1- methylcyclobutyl)amino)eth...)
Affinity DataKd:  1.40nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM710791((S)-6-(2-hydroxy-1-((1- methylcyclobutyl)amino)eth...)
Affinity DataIC50: 4.10nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM710791((S)-6-(2-hydroxy-1-((1- methylcyclobutyl)amino)eth...)
Affinity DataIC50: 4.90nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent