BDBM710808 2-(3-((2R)-2-(methoxymethyl)-1-(4-methyl- 4H-1,2,4-triazol-3-yl)cyclopropyl)phenyl)- 6-(((1-methylcyclobutyl)amino)methyl)-4- (trifluoromethyl)isoindolin-1-one::US12187709, Compound 166

SMILES COC[C@@H]1CC1(c5cccc(N4Cc3c(cc(CNC2(C)CCC2)cc3C(F)(F)F)C4=O)c5)c6nncn6C

InChI Key InChIKey=UOLRSTWIKBTUGC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710808   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710808BDBM710808(2-(3-((2R)-2-(methoxymethyl)-1-(4-methyl- 4H-1,2,4...)
Affinity DataKd:  710nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710808BDBM710808(2-(3-((2R)-2-(methoxymethyl)-1-(4-methyl- 4H-1,2,4...)
Affinity DataIC50: 1.90E+3nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 710808BDBM710808(2-(3-((2R)-2-(methoxymethyl)-1-(4-methyl- 4H-1,2,4...)
Affinity DataKd:  3.80E+3nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 710808BDBM710808(2-(3-((2R)-2-(methoxymethyl)-1-(4-methyl- 4H-1,2,4...)
Affinity DataIC50: 7.20E+3nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent