BDBM710953 4-chloro-2-(3-((1r,3R)-3-fluoro-1-(4- methyl-4H-1,2,4-triazol-3- yl)cyclobutyl)phenyl)-6-((R)-1-((1- methylcyclobutyl)amino)ethyl)isoindolin-1- one::US12187709, Compound 311

SMILES C[C@@H](NC1(C)CCC1)c1cc(Cl)c2c(c1)C(=O)N(c1cccc([C@]3(c4nncn4C)C[C@H](F)C3)c1)C2

InChI Key InChIKey=OHIWAMBAFXDJCL-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 710953   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM710953(4-chloro-2-(3-((1r,3R)-3-fluoro-1-(4- methyl-4H-1,...)
Affinity DataKd:  0.100nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM710953(4-chloro-2-(3-((1r,3R)-3-fluoro-1-(4- methyl-4H-1,...)
Affinity DataKd:  0.25nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM710953(4-chloro-2-(3-((1r,3R)-3-fluoro-1-(4- methyl-4H-1,...)
Affinity DataIC50: 4nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandPNGBDBM710953(4-chloro-2-(3-((1r,3R)-3-fluoro-1-(4- methyl-4H-1,...)
Affinity DataIC50: 4.30nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent