BDBM711053 4-(difluoromethyl)-2-(3-((R)-(4-methyl-4H- 1,2,4-triazol-3-yl)(oxetan-3- yl)methyl)phenyl)-6-((R)-1-((1- methylcyclobutyl)amino)methyl)isoindolin-1- one::US12187709, Compound 412

SMILES C[C@@H](NC1(C)CCC1)c1cc2c(c(C(F)F)c1)CN(c1cccc([C@H](c3nncn3C)C3COC3)c1)C2=O

InChI Key InChIKey=ZEYDBVDHJVJKOI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 711053   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 711053BDBM711053(4-(difluoromethyl)-2-(3-((R)-(4-methyl-4H- 1,2,4-t...)
Affinity DataKd:  5.20nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 711053BDBM711053(4-(difluoromethyl)-2-(3-((R)-(4-methyl-4H- 1,2,4-t...)
Affinity DataIC50: 14nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 711053BDBM711053(4-(difluoromethyl)-2-(3-((R)-(4-methyl-4H- 1,2,4-t...)
Affinity DataIC50: 59nMAssay Description:Table 3: Compounds were 3-fold serially diluted in DMSO in a 384-well polypropylene plate (#P-05525-BC; Labcyte) to generate a source plate with 10 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 711053BDBM711053(4-(difluoromethyl)-2-(3-((R)-(4-methyl-4H- 1,2,4-t...)
Affinity DataKd:  82nMAssay Description:Table 4: Chaser assay utilize a single cycle kinetics SPR experiment with a contact time of 120 seconds, a flow rate of 50 μl/min and a dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/19/2025
Entry Details
US Patent