BDBM711478 (2R)-2-(5-Chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3''-pyrrolidin]-1''-yl]propan-1-one ::US12187727, Example 15::US20250084084, Example 64

SMILES COc1cc([C@@H](C)C(=O)N2CC[C@@]3(CCc4cc(-c5ncccn5)c(C)nc4N3)C2)c(Cl)cn1

InChI Key InChIKey=AHFRNFYONJRGRW-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 711478   

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711478((2R)-2-(5-Chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  0.25nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711478((2R)-2-(5-Chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  0.25nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711478((2R)-2-(5-Chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  1nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711478((2R)-2-(5-Chloro-2-methoxypyridin-4-yl)-1-[(2S)-7-...)
Affinity DataKi:  94nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent