BDBM711481 (2R)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-{(2S)-7-methyl-6-[(4,6-2H2)pyrimidin-2-yl]-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3''-pyrrolidin]-1''-yl}propan-1-one ::US12187727, Example 18::US20250084084, Example 18

SMILES [2H]c1cc([2H])nc(-c2cc3c(nc2C)N[C@@]2(CC3)CCN(C(=O)[C@H](C)c3cc(OC)ncc3F)C2)n1

InChI Key InChIKey=PARGFYLSRQUWHR-XETGXLELSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 711481   

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711481((2R)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-{(2S)-7-...)
Affinity DataKi:  0.180nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711481((2R)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-{(2S)-7-...)
Affinity DataKi:  0.180nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent