BDBM711586 1-{(2S)-6-[5-(difluoromethyl)-1-methyl-1H-1,2,4-triazol-3-yl]-7-methyl-3,4-dihydro-1H-spiro[1 ,8-naphthyridine-2,3''-pyrrolidin]-1''-yl}-2-(6-methoxy-2-methylpyrimidin-4-yl)propan-1-one,DIAST-1::US12187727, Example 123::US20250084084, Example 124

SMILES COc1cc([C@@H](C)C(=O)N2CC[C@@]3(CCc4cc(-c5nc(C(F)F)n(C)n5)c(C)nc4N3)C2)nc(C)n1

InChI Key InChIKey=CXSZDOXXPORRNI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 711586   

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711586(1-{(2S)-6-[5-(difluoromethyl)-1-methyl-1H-1,2,4-tr...)
Affinity DataKi:  0.220nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711586(1-{(2S)-6-[5-(difluoromethyl)-1-methyl-1H-1,2,4-tr...)
Affinity DataKi:  0.220nMAssay Description:Compounds were solubilized in 100% dimethyl sulfoxide (DMSO) to a concentration of 30 mM. A 10-point intermediate dilution series using half log dilu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/20/2025
Entry Details
US Patent

TargetMelanocortin receptor 4(Human)
Pfizer

US Patent
LigandPNGBDBM711586(1-{(2S)-6-[5-(difluoromethyl)-1-methyl-1H-1,2,4-tr...)
Affinity DataKi:  6.70nMAssay Description:The binding affinity of test compounds at the α-melanocyte-stimulating hormone receptor (hMC4R) was assessed using a radioligand competition binding ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/17/2025
Entry Details
US Patent