BDBM713239 (Method 4):(E)-1-((R)-3-((7-(8-chloronaphthalen-1-yl)-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)(methyl)amino)pyrrolidin-1-yl)-3-(3-(oxetan-3-yl)-1,2,4-oxadiazol-5-yl)prop-2-en-1-one::US20250019387, Example 154

SMILES CN(c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c1CCN(c1cccc3cccc(Cl)c13)C2)[C@@H]1CCN(C(=O)/C=C/c2nc(C3COC3)no2)C1

InChI Key InChIKey=YVKALMAMFDRCNY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 713239   

LigandPNGBDBM713239((Method 4):(E)-1-((R)-3-((7-(8-chloronaphthalen-1-...)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50s for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
5/27/2025
Entry Details
US Patent