BDBM713310 (Method 8):(E)-1-(3-(((7-(8-chloro-7-fluoronaphthalen-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)(methyl)amino)methyl)azetidin-1-yl)-3-((R)-1-methylazetidin-2-yl)prop-2-en-1-one::US20250019387, Example 221

SMILES CN(CC1CN(C(=O)/C=C/[C@H]2CCN2C)C1)c1nc(OC[C@@]23CCCN2C[C@H](F)C3)nc2c(F)c(-c3cccc4ccc(F)c(Cl)c34)ncc12

InChI Key InChIKey=NNEJXSASJVCMPR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 713310   

LigandPNGBDBM713310((Method 8):(E)-1-(3-(((7-(8-chloro-7-fluoronaphtha...)
Affinity DataIC50: 10nMAssay Description:The AlphaScreen technology was used to determine IC50s for compound inhibition of KRAS G12C (present as the Cys-light (C51S, C80L and C118S), truncat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
5/27/2025
Entry Details
US Patent