BDBM716127 2-chloro-N-pyrimidin-4-yl-6- [rac-(1S,2S,4S)-2-(dimethyl- amino)-4-[3-(trifluoromethyl)- phenyl]cyclohexoxy]pyridine- 3-sulfonamide::US12209075, Example 22::US20250115576, Example 22

SMILES CN(C)[C@H]1C[C@@H](c2cccc(C(F)(F)F)c2)CC[C@@H]1Oc1ccc(S(=O)(=O)Nc2ccncn2)c(Cl)n1

InChI Key InChIKey=FEMOAPLKHCESRC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 716127   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716127(2-chloro-N-pyrimidin-4-yl-6- [rac-(1S,2S,4S)-2-(di...)
Affinity DataIC50: 2.21nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716127(2-chloro-N-pyrimidin-4-yl-6- [rac-(1S,2S,4S)-2-(di...)
Affinity DataIC50: 2.21nMAssay Description:Sodium currents are measured in the whole-cell configuration using Syncropatch 384PE (Hanlon Technologies, Germany). 1NPC®-384 chips with custom medi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM716127(2-chloro-N-pyrimidin-4-yl-6- [rac-(1S,2S,4S)-2-(di...)
Affinity DataIC50: 40nMAssay Description:A competitive NaV1.7 inhibitor having a methyl group is tritiated. Three tritiums are incorporated in place of methyl hydrogens to generate [3H]compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent