BDBM716374 US20250034108, Example Rac-27

SMILES CC(O)(CS(N)(=O)=O)c1ccc(Cl)c(-c2nnn(Cc3cc(OC(F)(F)F)ccc3F)n2)n1

InChI Key InChIKey=HXHMZCKTHIDEJW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 716374   

TargetSodium channel protein type 5 subunit alpha(Human)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 716374BDBM716374(US20250034108, Example Rac-27)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human Nav1.5 expressed in CHO-K1 cells preincubated for 3 mins followed by incubation under atrial fibrillation-mimicking condition at ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 716374BDBM716374(US20250034108, Example Rac-27)
Affinity DataIC50: 1.10E+3nMAssay Description:To assess peak Nav1.5 current inhibition in an atrial fibrillation-mimicking condition (Nav1.5 IC50 (5 Hz, AF-like rate) (μM)), compounds were first ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 716374BDBM716374(US20250034108, Example Rac-27)
Affinity DataIC50: 1.60E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Emory University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 716374BDBM716374(US20250034108, Example Rac-27)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human Nav1.5 expressed in CHO-K1 cells preincubated with compound for 3 mins in presence of ATXII followed by incubation under ventricu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed