BDBM718922 6-((10R,13aR)-11-chloro-9- fluoro-7-(((S)-2- methylenetetrahydro-1H- pyrrolizin-7a(5H)-yl)methoxy)- 1,2,3,4,13,13a- hexahydropyrazino[2'', 1'':3,4][1,4] oxazepino[5,6,7-de]quinazolin- 10-yl)-4-methyl-5- (trifluoromethyl)pyridin-2-amine::US20250042919, Compound 13A

SMILES C=C1CN2CCC[C@@]2(COc2nc3c4c(c(Cl)c(-c5nc(N)cc(C)c5C(F)(F)F)c(F)c4n2)OC[C@H]2CNCCN32)C1

InChI Key InChIKey=JAOVBJHENSECEC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718922   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718922(6-((10R,13aR)-11-chloro-9- fluoro-7-(((S)-2- methy...)
Affinity DataIC50: 0.700nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718922(6-((10R,13aR)-11-chloro-9- fluoro-7-(((S)-2- methy...)
Affinity DataIC50: 0.800nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent