BDBM718938 6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((2S,4R)-4-fluoro-1- methylpyrrolidin-2-yl)methoxy)-5- methyl-5a,6,7,8,9,10-hexahydro- 5H-6,9- epiminoazepino[2'', 1'':3,4][1,4] oxazepino[5,6,7-de]quinazolin- 2-yl)-4-methyl-5- (trifluoromethyl)pyridin-2-amine::US20250042919, Compound 25

SMILES Cc1cc(N)nc(-c2c(Cl)c3c4c(nc(OC[C@@H]5C[C@@H](F)CN5C)nc4c2F)N2C[C@H]4CC[C@H](N4)[C@H]2[C@H](C)O3)c1C(F)(F)F

InChI Key InChIKey=VHWSOUINMHLXET-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718938   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718938(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((2S,4...)
Affinity DataIC50: 0.200nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718938(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((2S,4...)
Affinity DataIC50: 46nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent