BDBM718941 6-((2R,5S,5aS,6S,9R)-3-chloro- 13-(((3S)-2'',2''-difluoro-1- azaspiro[bicyclo[3.2.0]heptane- 3,1''-cyclopropan]-5-yl)methoxy)- 1-fluoro-5-methyl-5a,6,7,8,9,10- hexahydro-5H- [6,9]epiminoazepino[2'', 1'':3,4] [1,4]oxazepino[5,6,7- de]quinazolin- 2-yl)-4-methyl-5- (trifluoromethyl)pyridin-2-amine::US20250042919, Compound 28

SMILES Cc1cc(N)nc(-c2c(Cl)c3c4c(nc(OCC56CCN5C[C@]5(C6)CC5(F)F)nc4c2F)N2C[C@H]4CC[C@H](N4)[C@H]2[C@H](C)O3)c1C(F)(F)F

InChI Key InChIKey=ICVQONGJEDYHAN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718941   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718941(6-((2R,5S,5aS,6S,9R)-3-chloro- 13-(((3S)-2',2'-dif...)
Affinity DataIC50: 0.118nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718941(6-((2R,5S,5aS,6S,9R)-3-chloro- 13-(((3S)-2',2'-dif...)
Affinity DataIC50: 1.5nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent