BDBM718951 6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((3R)-3-fluoro-1- azabicyclo[3.2.0]heptan-5- yl)methoxy)-5-methyl- 5a,6,7,8,9,10-hexahydro-5H-6,9- epiminoazepino[2'', 1'':3,4][1,4] oxazepino[5,6,7-de]quinazolin- 2-yl)-4-methyl-5- (trifluoromethyl)pyridin-2-amine::US20250042919, Compound 37

SMILES Cc1cc(N)nc(-c2c(Cl)c3c4c(nc(OC[C@@]56CCN5C[C@H](F)C6)nc4c2F)N2C[C@H]4CC[C@H](N4)C2[C@H](C)O3)c1C(F)(F)F

InChI Key InChIKey=QYGHJBNFPXIQSK-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718951   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718951(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((3R)-...)
Affinity DataIC50: 0.134nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718951(6-((2R,5S,5aS,6S,9R)-3-chloro- 1-fluoro-13-(((3R)-...)
Affinity DataIC50: 8.29nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent