BDBM718956 US20250042919, Compound 41A

SMILES C[C@@H]1Oc2c(Cl)c(-c3nc(N)ccc3C(F)(F)F)c(F)c3nc(OC[C@@]45CCN4C[C@]4(CC4(F)F)C5)nc(c23)N2C[C@H]3CC[C@H](N3)[C@@H]12

InChI Key InChIKey=OLKYWRLVWRJKOQ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718956   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718956(US20250042919, Compound 41A)
Affinity DataIC50: 0.115nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718956(US20250042919, Compound 41A)
Affinity DataIC50: 7.52nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent