BDBM718965 6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((2R,7aS)-2- fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-15- methyl-5a,6,7,8,9,10-hexahydro-5H-9,6- (epiminomethano)azepino[2'',1'':3,4][1,4]oxazepino[5,6,7- de]quinazolin-2-yl)-4-methyl-5-(trifluoromethyl)pyridin- 2-amine::US20250042919, Compound 46

SMILES Cc1cc(N)nc(-c2c(Cl)c3c4c(nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c2F)N2C[C@H]4CC[C@H](CN4C)[C@H]2CO3)c1C(F)(F)F

InChI Key InChIKey=ZUSLDNYYHXEUFZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718965   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718965(6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((2R,7aS)-...)
Affinity DataIC50: 0.370nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718965(6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((2R,7aS)-...)
Affinity DataIC50: 16.7nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent