BDBM718968 6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((S,Z)-2- (fluoromethylene)tetrahydro-1H-pyrrolizin-7a(5H)- yl)methoxy)-5a,6,7,8,9,10-hexahydro-5H-9,6- (epiminomethano)azepino[2'',1'':3,4][1,4]oxazepino[5,6,7- de]quinazolin-2-yl)-4-methyl-5-(trifluoromethyl)pyridin- 2-amine::US20250042919, Compound 49

SMILES Cc8cc(N)nc(c7c(F)c3nc(OC[C@@]12CCCN1C/C(=C/F)C2)nc4c3c(OC[C@@H]5[C@@H]6CC[C@H](CN45)NC6)c7Cl)c8C(F)(F)F

InChI Key InChIKey=KXULEPSYISNRFK-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 718968   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM718968(6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((S,Z)-2- ...)
Affinity DataIC50: 0.325nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM718968(6-((2R,5aS,6R,9R)-3-Chloro-1-fluoro-13-(((S,Z)-2- ...)
Affinity DataIC50: 11.5nMAssay Description:KRAS Biochemical Assay—BODIPY-GDP Exchange TR-FRET. Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/12/2025
Entry Details
US Patent