BDBM719127 US20250049780, Example 53

SMILES Cc1nc2c3c(c(-c4[nH]c5sc(C6CCN(C(=O)[C@H]7COCCN7)CC6)c(C)c5c4C(C)C)cn2n1)CCC3

InChI Key InChIKey=USZGFGAWPHDSGO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 719127   

TargetToll-like receptor 7(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719127(US20250049780, Example 53)
Affinity DataEC50:  0.620nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) consist of lymphocytes, monocytes and dendritic cells that express TLR7, TLR8 and TLR9. These cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent

TargetToll-like receptor 8(Human)
Gilead Sciences

US Patent
LigandPNGBDBM719127(US20250049780, Example 53)
Affinity DataEC50:  16.2nMAssay Description:Cryopreserved human PBMCs from healthy donors were thawed and resuspended in RPMI-1640 media with L-glutamine (Corning) supplemented with 10% Fetal B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/16/2025
Entry Details
US Patent